RDX has also been found in the Holston River as far south as Knoxville, more than 100 miles downstream. However, environmental contaminants and toxic spills have eradicated mussels from a section of the river where the fauna was once diverse and abundant.

The Virginia Department of Environmental Quality held two informational meetings, the other in Saltville, to explain a study on approximately 82 North Fork river miles stretching from Saltville to the Tennessee state line.

The Ohio River seems to be the most polluted river in North America, although it made some progress since the installment of the Clean Water Act. The Clinch River in southwestern Virginia and eastern Tennessee contains roughly 45 species of freshwater mussels. to the Holston River well in excess of the health-based limitation imposed by National Pollutant Discharge Elimination System (“NPDES”) Permit TN0003671 each and every month since the limit became effective in May 2012. Those memories were one reason Larkey attended the North Fork Holston River Mercury TMDL public meeting in Hiltons last week. The North Fork of the Holston River, which flows through Saltville to Tennessee, is so spiked with quicksilver that people can't eat the fish. Actual development of the model is being carried out with the Tennessee Valley Authority (TVA) for the Holston River watershed.The effort includes model construction by importation of GIS map files, stringing together existing watershed and reservoir models, calibration of the model, and selection of decision variables and water quality check points. Rank River/Waterbody States with toxic discharges contributing to water pollution Total pounds of direct toxic discharges to water (1990-1994) 1 Mississippi River TN, AR, LA, MO, IL, MN, WI, IA, KY, MS 702,496,748 2 Pacific Ocean OR, HI, CA 35,195,908 3 Ohio River IL, IN, OH, KY, WV, PA 22,072,491 4 Tennessee River KY, TN, AL 22,031,743 5 Houston Ship Channel TX 18,235,338 6 . Arguably, the Mississippi River, the Ohio River, and the Holston River are the top three most polluted rivers in the U.S.